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Protease Genotypes in Patients Failing Protease Inhibitor–based Antiretroviral Therapy at a Pediatric Center in Botswana

Gomila, Andres MD; Kirk, Brianna MD; Marape, Marape MBBCh, BAO, MPH, PhD; Anabwani, Gabriel MD, MSc; Tolle, Michael MD, MPH

The Pediatric Infectious Disease Journal: October 2013 - Volume 32 - Issue 10 - p 1086–1088
doi: 10.1097/INF.0b013e318294c922
HIV Reports

With increasing use of protease inhibitors (PI) in Botswana, a large proportion of HIV-infected children are now exposed to PI-based regimens. There is limited protease genotype data from African children and adolescents who have failed PI-based antiretroviral therapy. We describe a cohort of pediatric HIV-infected patients experiencing virologic failure at time of second-line or salvage PI-based regimens and analyze associated PI mutations.

Supplemental Digital Content is available in the text.

From the Botswana-Baylor Children’s Clinical Centre of Excellence, Gaborone, Botswana, and Baylor College of Medicine, Houston, TX.

Accepted for publication March 21, 2013.

The authors have no funding or conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (

Address for correspondence: Andres Gomila, MD, Botswana-Baylor Children’s Clinical Centre of Excellence, Plot 1836, Hospital Way, Gaborone, Botswana. E-mail:

© 2013 by Lippincott Williams & Wilkins, Inc.