Immunology ReportsEven in Pneumococcal Sepsis CD62L Shedding on Granulocytes Proves to be a Reliable Functional Test for the Diagnosis of Interleukin-1 Receptor–associated Kinase-4 DeficiencyAndres, Oliver MD*; Strehl, Karoline Cand. Med.†; Kölsch, Uwe MD‡§; Kunzmann, Steffen MD*; Lebrun, Anne-Hélène PhD†; Stroh, Thorsten PhD¶; Schwarz, Klaus MD‖; Morbach, Henner MD*; von Bernuth, Horst MD, PhD†‡; Liefse, Johannes MD, MSc* Author Information From the *Division of Pediatric Infectious Diseases and Immunology and Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University of Würzburg, Würzburg, Germany; †Department of Pediatric Pneumology and Immunology, Charité Children’s Hospital; ‡Division of Immunology, Labor Berlin; §Institute of Medical Immunology, Charité, Campus Virchow Klinikum; ¶Medical Department I, Charité—Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; and ‖Institute for Clinical Transfusion Medicine and Immunogenetics, Ulm, German Red Cross Blood Service, Baden-Württemberg-Hessen, and Institute for Transfusion Medicine, University Hospital Ulm, Ulm, Germany. Accepted for publication March 08, 2013. O.A., Ka.St., H.v.B. and J.L. contributed equally to this publication. H.v.B. received a grant (BE-3895/3-1) from the Deutsche Forschungsgemeinschaft and a grant from the Sonnenfeldstiftung. The authors have no other funding or conflicts of interest to disclose. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.pidj.com). Address for correspondence: Oliver Andres, MD, Division of Neonatology and Pediatric Intensive Care, University Children’s Hospital, Josef-Schneider-Straße 2, 97080 Würzburg, Germany. E-mail: [email protected]. The Pediatric Infectious Disease Journal: September 2013 - Volume 32 - Issue 9 - p 1017-1019 doi: 10.1097/INF.0b013e318292bf8c Buy SDC Erratum Metrics Abstract A 9-month-old infant presented with fatal pneumococcal sepsis and attenuated inflammation indices. Even in septic conditions, flow cytometry–based CD62L shedding test on granulocytes proved to be a fast and reliable diagnostic tool for the detection of a defect in the innate immunity. Confirmatory immunologic and genetic assays identified an autosomal-recessive interleukin-1 receptor–associated kinase-4 deficiency due to compound heterozygous mutations. Erratum In the article on page 1017, volume 32, issue 9 of The Pediatric Infectious Disease Journal the last author’s name was misspelled. The correct spelling of the last author’s name is Johannes Liese, MD, MSc. The Pediatric Infectious Disease Journal. 32(11):1302, November 2013. © 2013 by Lippincott Williams & Wilkins, Inc.