We measured glucose, insulin and lipids in 249 perinatally HIV-infected Latin American children. Only 1 subject had impaired fasting glucose; 6.8% had insulin resistance. Abnormalities in total, low-density lipoprotein and high-density lipoprotein cholesterol and triglycerides were reported for 13%, 13%, 21% and 34%, respectively. Continued follow-up of this population is necessary to characterize the evolution and clinical consequences of these findings.
From the * Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD; †Westat, Rockville, MD; ‡University of São Paulo, Ribeirão Preto, SP, Brazil; §Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico; ¶Federal University of São Paulo, São Paulo; ‖Hospital Federal dos Servidores do Estado, Rio de Janeiro; and **Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Brazil.
Supported by NICHD Contract # HHSN267200800001C (NICHD Control # N01-HD-8-0001). The authors have no other funding or conflicts of interest to disclose.
Address for correspondence: Rohan Hazra, MD, Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Room 4B11, Bethesda, MD 20892–7510. E-mail: email@example.com.