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Incidence and Characteristics of Sporadic Norovirus Gastroenteritis Associated with Hospitalization of Children Less Than 5 Years of Age in Israel

Muhsen, Khitam PhD*†; Kassem, Eias MD; Rubinstein, Uri MD§; Schachter, Yaakov MD§; Kremer, Adi MD; Goren, Sophy BSc*; Zilberstein, Ilana MSc; Ephros, Moshe MD‖ **; Cohen, Dani PhD*; Shulman, Lester M. PhD

The Pediatric Infectious Disease Journal: June 2013 - Volume 32 - Issue 6 - p 688–690
doi: 10.1097/INF.0b013e318287fc81
Brief Reports

The incidence of sporadic GII norovirus gastroenteritis associated with hospitalization was examined among 515 children aged <5 years in a prospective study in Israel. Using real-time polymerase chain reaction, norovirus was detected in stools of 89 (17.3%) children, yielding an estimated incidence of 3.3 per 1000 children. Genotypes GII.3 (40.4%) and GII.4a (21.3%) predominated, though year-to-year variation was observed.

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From the *Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Medicine, Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD; Departments of Pediatrics Hillel Yaffe Medical Center, Hadera; §Departments of Pediatrics Laniado Medical Center, Natanya; Medical Central Virology Laboratory, Ministry of Health, Tel Hashomer; Pediatric Infectious Disease Unit, Carmel Medical Center, Haifa; **Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

The first year of the study was supported by the Department of Immunization, Vaccination and Biologicals, World Health Organization (V27-181-190).

The authors have no other funding or conflicts of interest to disclose.

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Address for correspondence: Khitam Muhsen, PhD, Center for Vaccine Development, University of Maryland, School of Medicine, 685 West Baltimore Street, HSF-II room 480, Baltimore, MD 21201. E-mail:,

© 2013 Lippincott Williams & Wilkins, Inc.