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Seroreversion of Treponemal Tests in Infants Meeting Canadian Surveillance Criteria for Confirmed Early Congenital Syphilis

Singh, Ameeta E. BMBS, MSc*†; Guenette, Tamara RN, BScN*; Gratrix, Jennifer RN, MSc*; Bergman, Joshua RN, BScN*; Parker, Penny RN, BN*; Anderson, Barbara RN, MSc*; Plitt, Sabrina S. PhD; Lee, Bonita E. MD, MSc; Robinson, Joan L. MD

The Pediatric Infectious Disease Journal: March 2013 - Volume 32 - Issue 3 - p 199–202
doi: 10.1097/INF.0b013e318273599c
Original Studies

Background: Few data exist on the serologic outcome of treponemal tests in congenital syphilis.

Methods: A chart review was conducted on all confirmed early congenital syphilis cases in Edmonton, Canada, from 2005-2010.

Results: Of the 16 cases identified, 11 (69%) infants seroreverted their treponemal tests by 18 months. Cases that did not serorevert their treponemal tests were statistically more likely to have delayed treatment and to have higher maternal rapid plasma reagin titers at birth.

Conclusions: Our data suggest that the majority of early congenital syphilis cases will serorevert their treponemal tests by 18 months.

From the *Alberta Health Services—Edmonton STI Clinic; University of Alberta, Edmonton, Alberta; and Public Health Agency of Canada, Ottawa, Ontario, Canada.

Accepted for publication September 07, 2012.

The authors have no funding or conflicts of interest to disclose.

Presented as a poster presentation at the International Society for STD Research, Quebec City, Canada, July 10–13, 2011 (Sex Transm Infect 2011;87;suppl 1).

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Address for correspondence: Ameeta E. Singh, BMBS, MSc, FRCP(C), c/o Alberta Health Services—Edmonton STI Clinic, 3B20-11111 Jasper Avenue, Edmonton, Alberta, T5K 0L4. E-mail:

© 2013 Lippincott Williams & Wilkins, Inc.