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Ocular Manifestations Of Candidemia In Children

Fierro, Julie L. BA*; Prasad, Priya A. MPH*; Fisher, Brian T. DO, MSCE*†‡; Gerber, Jeffrey S. MD, PhD, MSCE*†‡; Coffin, Susan E. MD, MPH*†‡; Walsh, Thomas J. MD; Zaoutis, Theoklis E. MD, MSCE*†‡§

The Pediatric Infectious Disease Journal: January 2013 - Volume 32 - Issue 1 - p 84–86
doi: 10.1097/INF.0b013e31826f547c
Brief Reports

Among 254 patients with candidemia who had a dilated retinal examination, 8 patients (3.2%) were diagnosed with ocular disease resulting in retinal detachment in 2 patients and globe rupture in 1 patient. This study found that ocular candidiasis is an uncommon but serious sight-threatening complication in pediatric patients with candidemia.

From the *Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, Department of Pediatrics, The Children’s Hospital of Philadelphia, §Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA; and Transplantation-Oncology Infectious Diseases Program, Weill Cornell Medical Center of Cornell University, New York, NY.

This work was supported by the National Institutes of Health (1K23 AI0629753-01 to TEZ) and Merck Research Funding. This study was supported in part by the intramural research program of the National Cancer Institute. TEZ has received research funding from Merck-Schering-Plough (Whitehouse Station, NJ) and Enzon (Piscataway, NJ) and has received speaking honoraria from Cephalon (Frazer, PA). The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Theoklis E. Zaoutis, MD, MSCE, The Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104. E-mail:

© 2013 Lippincott Williams & Wilkins, Inc.