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Ethanol Locks Therapy for Resolution of Fungal Catheter Infections

Blackwood, Roland Alexander MD, PhD*; Klein, Kristin C. PharmD; Micel, Lindsey N. MD; Willers, Michelle L.*; Mody, Rajen J. MD§; Teitelbaum, Daniel H. MD; Cober, M. Petrea PharmD, BCNSP**

The Pediatric Infectious Disease Journal: December 2011 - Volume 30 - Issue 12 - p 1105–1107
doi: 10.1097/INF.0b013e31822c84a4
Brief Reports

Ethanol locks have been used to treat catheter infections and to decrease the rate at which they occur. Catheter-related infections caused by Candida spp. are especially difficult to manage medically and usually require catheter removal. We report 3 consecutive patients whose catheter infections caused by Candida were successfully treated with a combination of ethanol lock therapy and systemic antifungals.

From the *Pediatric Infectious Diseases, University of Michigan, Ann Arbor, MI; †University of Michigan, Ann Arbor, MI; ‡Pediatric Hematology/Oncology, The Children's Hospital, University of Colorado, Aurora, CO; §Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI; ¶Pediatric Surgery, University of Michigan, Ann Arbor, MI; and **College of Pharmacy, Northeastern Ohio University, Rootstown, OH.

Accepted for publication July 6, 2011.

Supported by a sole-source grant from Blue Cross Blue Shield of Michigan Foundation, Project 1292.II (Dr. Blackwood, principal investigator).

The authors have no other funding or conflicts of interest to disclose.

Address for correspondence: Roland Alexander Blackwood, MD, PhD, University of Michigan, 1500 East Medical Center Drive, D5101 Medical Professional Building, SPC 5718, Ann Arbor, MI 48109-5718. E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.