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An Outbreak of Adenovirus Type 7 in a Residential Facility for Severely Disabled Children

Ghanaiem, Hammam MD*; Averbuch, Diana MD*; Koplewitz, Benjamin Z. MD; Yatsiv, Ido MD; Braun, Jackues MD; Dehtyar, Natali MD§; Wolf, Dana G. MD; Mandelboim, Michal PhD; Engelhard, Dan MD***††

The Pediatric Infectious Disease Journal: November 2011 - Volume 30 - Issue 11 - p 948-952
doi: 10.1097/INF.0b013e31822702fe
Original Studies

Background: Adenoviruses cause a variety of clinical symptoms, involving the respiratory, gastrointestinal, urogenital, and neurologic systems. Only a few of the 55 known serotypes of adenovirus that affect humans can cause outbreaks of respiratory tract infection.

Aim: To describe the characteristics and clinical manifestations of severe respiratory disease contracted by 8 physically and cognitively disabled children during a very short outbreak of adenovirus serotype 7 infection in a residential facility.

Methods: The clinical, imaging, and laboratory findings of the patients who were hospitalized with severe respiratory symptoms were retrospectively reviewed. Molecular typing of the adenovirus was performed.

Results: During 10 days in February 2010, 8 severely disabled children, 9 months to 5 years of age (median 22.5 months), from the same residential facility, were hospitalized due to severe acute respiratory disease with hypoxemia. Four of them (50%) needed mechanical ventilation for 2 to 8 days and one developed multisystem failure, including acute renal failure. Adenovirus serotype 7 was detected in the respiratory specimens of all 8 children. Two patients were treated with intravenous cidofovir. All 8 patients survived and were discharged after hospitalization of 6 to 15 (median: 11.5) days. The epidemiologic investigation revealed that all the 8 affected children shared a playroom and a caregiver worked with them while suffering fever, sore throat, and conjunctivitis before the onset of the outbreak.

Conclusions: Adenovirus type 7 may cause short outbreaks of infection in institutions, causing children to develop life-threatening disease. Early detection of pathogens causing respiratory infections in institutions, isolation, and other preventive precautions are advocated. Moreover, vaccination of health care providers in institutions with the currently available live, oral adenovirus vaccine for types 4 and 7 should be considered.

From the *Department of Pediatrics, †Department of Medical Imaging, and ‡Pediatric Intensive Care Unit, Hadassah University Hospital, Jerusalem, Israel; §“Aleh” Pediatric Long Term Care Facility, Jerusalem, Israel; ¶Clinical Virology Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; ∥Virology Laboratory, Sheba Medical Center, Tel-Hashomer, Israel; **Clara & Seymour Smoller Chair in Pediatrics, Hadassah-Hebrew University Hospital, Jerusalem, Israel; and ††The School of Primary Health Care, Monash University, Melbourne, Australia.

Accepted for publication May 31, 2011.

H.G. and D.A. contributed jointly to this manuscript.

The authors have no funding or conflicts of interest to disclose.

Address for correspondence: Dan Engelhard, MD, Head of Pediatric Department, Head, Pediatric AIDS Center and Pediatric Infectious Diseases, Hadassah University Hospital, Ein-Kerem, Jerusalem, Israel. E-mail:

© 2011 by Lippincott Williams & Wilkins, Inc.