Neonatal Bacterial Meningitis: 444 Cases in 7 Years : The Pediatric Infectious Disease Journal

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Neonatal Bacterial Meningitis

444 Cases in 7 Years

Gaschignard, Jean MD*; Levy, Corinne MD†‡; Romain, Olivier MD*†‡; Cohen, Robert MD†‡; Bingen, Edouard MD†§; Aujard, Yannick MD†‡¶; Boileau, Pascal MD*

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The Pediatric Infectious Disease Journal 30(3):p 212-217, March 2011. | DOI: 10.1097/INF.0b013e3181fab1e7



Neonatal bacterial meningitis remains a severe infectious disease with mortality rates varying between 10% and 15%. The clinical and bacteriologic features of neonatal meningitis collected from January 2001 to December 2007 in a French national survey are presented here.


Cases of neonatal meningitis were prospectively collected by a network of 252 pediatric wards covering 61% of French pediatric wards, associated with 168 microbiology laboratories. Neonatal meningitis was classified as early-onset (d0–d4) and late-onset (d5–d28). Statistical analyses were performed according to gestational age and weight at birth.


A total of 444 cases of neonatal bacterial meningitis were reported by 114 pediatric wards. Five cases were excluded from analysis. Group B streptococci (GBS) and Escherichia coli accounted respectively for 59% and 28% of the cases, followed by Gram-negative bacilli other than E. coli (4%), other streptococci (4%), Neisseria meningitidis (3%), and Listeria monocytogenes (1.5%). GBS was the most common pathogen both in early-onset (77% vs. 18% for E. coli) and in late-onset meningitis (50% vs. 33% for E. coli). Among preterm infants, E. coli was more commonly isolated (45% vs. 32% for GBS), especially in very preterm infants (54%). GBS was more often involved in seizures than E. coli (41% vs. 25%). The overall mortality rate was 13% but reached 25% in preterm or small for gestational age infants, regardless of the etiology.


GBS was the dominant cause of neonatal bacterial meningitis, with 77% of early-onset and 50% of late-onset cases. E. coli was the most common bacteria in preterm infants.

© 2011 Lippincott Williams & Wilkins, Inc.

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