Reported neurologic manifestations of novel H1N1 influenza have included seizure, meningoencephalitis, and acute necrotizing encephalopathy. We describe the first series of pediatric patients presenting during the second wave of the US novel H1N1 pandemic, with protracted seizures, severe encephalopathy/encephalitis, and acute disseminated encephalomyelitis. In addition to prominent radiographic abnormalities, we provide the first observation and description of associated cerebrospinal fluid abnormalities.
From the *Division of Pediatric Infectious Diseases, Children's National Medical Center, Washington, DC; Departments of †Medicine and ‡Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN; §Department of Pediatrics, Emory University School of Medicine, Atlanta, GA; and ¶Department of Pediatrics, The George Washington University School of Medicine, Washington, DC.
Accepted for publication July 20, 2010.
Address for correspondence: Roberta L. DeBiasi, MD, Division of Pediatric Infectious Diseases, Children's National Medical Center, 111 Michigan Ave, NW, West Wing 3.5, Washington, DC 20010. E-mail: firstname.lastname@example.org.