Institutional members access full text with Ovid®

Share this article on:

Association of Meningococcal Phenotypes and Genotypes With Clinical Characteristics and Mortality of Meningitis in Children

Levy, Corinne MD*†; Taha, Muhamed-Kheir MD‡§; Weil Olivier, Catherine MD*; Quinet, Beatrice MD*; Lecuyer, Aurélie MD*†; Alonso, Jean Michel MD; Aujard, Yannick MD*; Bingen, Edouard PhD*; Cohen, Robert MD*†Groupe des pédiatres et microbiologistes de l'Observatoire National des Méningites

The Pediatric Infectious Disease Journal: July 2010 - Volume 29 - Issue 7 - p 618-623
doi: 10.1097/INF.0b013e3181d3ce32
Original Studies

Background: Neisseria meningitidis meningitis represents approximately one-half of the meningococcal cases in French children. To explore the contribution of bacterial typing in improving the management of cases, we aimed to describe clinical characteristics and mortality of meningococcal meningitis in children reported to the multicenter survey system, GPIP/ACTIV, in association with phenotypes/genotypes of bacterial isolates.

Methods: From 2001 to 2005, 259 pediatric wards and 168 microbiology laboratories enrolled all children with bacterial meningitis. Risk factors, vaccination status, signs and symptoms, cerebrospinal fluid analysis, treatments and case fatality rate were recorded.

Results: A total of 962 cases of Neisseria meningitidis meningitis among a total of 2131 bacterial meningitis (45%) were recorded (mean age, 4.5 ± 4.7 years). Serogroup distribution of the isolates was 62.3%, 33.7%, 2.9%, 0.6%, and 0.6% for serogroups B, C, W135, A and Y, respectively. The major clonal complexes were ST-41/44 (32.2%), ST-11 (21.9%), ST-32 (20.8%), ST-8 (8.2%), and ST-269 (4.9%). Despite global heterogeneity of the isolates, 2 phenotypes/genotypes were of interest. Isolates of the phenotype/genotype B:14:P1.7,16/ST-32 (56% clustered in the region of Haute Normandie) were observed in older children (8.6 years) and were associated with a higher case fatality rate (12%) than were other phenotypes of serogroup B. The phenotype/genotype C:2a:P1.5/ST-11 was found in 26.3% of serogroup C cases and was possibly associated with a higher mortality among serogroup C (9.9% for C and 5.9% for B, P = 0.04).

Conclusions: This large survey provides data that could be important for implementation of future vaccines. Typing of meningococcal isolates could contribute to an understanding of prognosis in meningococcal meningitis.


From the *GPIP (Groupe de Pathologie Infectieuse Pédiatrique) de la SFP (Société Française de Pédiatrie), Paris, France; †ACTIV (Association Clinique et Thérapeutique Infantile du Val de Marne), Paris, France; ‡Institut Pasteur, Centre National de Référence des méningocoques, Paris, France; and §Institut Pasteur Invasive Bacterial Infections Unit Paris, France.

Accepted for publication January 11, 2010.

Supported by the Pediatric Infectious Diseases Group of the French Pediatrics Society (GPIP) and Association Clinique et Therapeutique Infantile du Val de Marne (ACTIV).

Address for correspondence: Robert Cohen, MD, CHI Créteil, 40 Avenue de Verdun, Créteil 94000, France. E-mail: and

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

© 2010 Lippincott Williams & Wilkins, Inc.