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Focal Epithelial Hyperplasia Caused by Human Papillomavirus 13

Saunders, Natasha R. MSc, MD*†; Scolnik, Dennis MSc, MB ChB, DCH, FRCP(C)†‡§; Rebbapragada, Anuradha PhD; Koelink, Eric MD*†; Craw, Lindsey MD*†; Roth, Sherryn MD, FRCP(C); Aronson, Leya RN; Perusini, Stephen PhD; Silverman, Michael S. MD, FRCP, FACP§**

The Pediatric Infectious Disease Journal: June 2010 - Volume 29 - Issue 6 - p 550-552
doi: 10.1097/INF.0b013e3181cf854c
Instructive Cases

Focal epithelial hyperplasia is a benign, papulo-nodular disease of the oral cavity. It is rare, affecting primarily Native American populations during childhood. It is closely associated with human papillomavirus 13 and 32. This report describes the diagnosis of 2 cases of focal epithelial hyperplasia in children from southern Guyana. The diagnosis was made using clinical criteria, polymerase chain reaction, and DNA sequencing.

From the *Department of Pediatrics, Hospital for Sick Children, Toronto, Canada; †Department of Medicine, The University of Toronto, Toronto, Canada; ‡Division of Pediatric Emergency Medicine, The Hospital for Sick Children, Toronto, Canada; §The Peter A Silverman Centre for International Health, Toronto, Canada; ¶Ontario Agency for Health Protection and Promotion, Public Health Laboratory, Toronto, Canada; ∥Department of Medicine, The Scarborough Hospital, Toronto, Canada; and **Department of Medicine, Division of Infectious Diseases, Lakeridge Health Centre, Oshawa, Canada.

Accepted for publication December 11, 2009.

There are no financial disclosures from any of the authors.

Address for correspondence: Michael S. Silverman, MD, FRCP, FACP, Division of Infectious Diseases and Internal Medicine, Lakeridge Health Centre, Oshawa, Ontario, Canada. E-mail:

© 2010 Lippincott Williams & Wilkins, Inc.