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Rotavirus Meningoencephalitis in a Previously Healthy Child and a Review of the Literature

Dickey, Michelle MS, APRN*; Jamison, Linda MS, RN*; Michaud, Linda MD; Care, Marguerite MD; Bernstein, David I. MD, MA*; Staat, Mary Allen MD, MPH*

The Pediatric Infectious Disease Journal: April 2009 - Volume 28 - Issue 4 - p 318-321
doi: 10.1097/INF.0b013e31818ddbe9
Instructive Case

A 31/2-year-old child presented with symptoms of acute gastroenteritis and evidence of central nervous system disease. Evaluation revealed findings consistent with meningoencephalitis and rotavirus detected in the cerebrospinal fluid by polymerase chain reaction. A review of the literature describes 23 cases of central nervous system disease attributed to rotavirus.


From the *Division of Infectious Disease, Department of Pediatrics, †Division of Pediatric Rehabilitation, and ‡Department of Radiology, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Accepted for publication September 15, 2008.

Mary Allen Staat and David Bernstein had or currently have funding as consultants or from research from the vaccine companies with current or past involvement in the development of rotavirus vaccines (Wyeth-Lederle Vaccines, GlaxoSmithKline, and Merck Laboratories); and David Bernstein receives royalties from GlaxoSmithKline as well.

Address for correspondence: Mary Allen Staat, MD, MPH, Cincinnati Children's Hospital Medical Center, 3333 Burnet Road, Cincinnati, OH, 45229. E-mail:

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© 2009 Lippincott Williams & Wilkins, Inc.