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Peripheral Neuropathy in an Adolescent Treated With Linezolid

Linam, W Matthew MD*†; Wesselkamper, Kristen MD; Gerber, Michael A. MD*

The Pediatric Infectious Disease Journal: February 2009 - Volume 28 - Issue 2 - p 149-151
doi: 10.1097/INF.0b013e3181945999
Instructive Case

The increased incidence of methicillin-resistant Staphyloccocus aureus infections may increase linezolid use in children. Peripheral neuropathy is a rare adverse effect of linezolid therapy and is more frequent with prolonged courses. We present an adolescent with peripheral neuropathy after 4 months of linezolid therapy and review the literature related to linezolid-induced neuropathies. Children receiving long-term linezolid therapy should be monitored for neuropathy.

From the Divisions of *Pediatric Infectious Diseases, †Healthcare Quality and Clinical Effectiveness, and ‡Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Accepted for publication November 7, 2008.

Address for correspondence: W. Matthew Linam, MD, Division of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5019, Cincinnati, OH 45229-3039. E-mail:

© 2009 Lippincott Williams & Wilkins, Inc.