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Empiric Antibiotic Therapy for Acute Osteoarticular Infections With Suspected Methicillin-Resistant Staphylococcus aureus or Kingella

Section Editor(s): Grose, Charles MD

The Pediatric Infectious Disease Journal: August 2008 - Volume 27 - Issue 8 - p 765-767
doi: 10.1097/INF.0b013e31816fc34c

The bacterial agents causing bone and joint infections have been changing. Currently, methicillin-resistant Staphylococcus aureus (MRSA) and Kingella kingae are emerging pathogens. For treatment of MRSA infections, clindamycin, vancomycin, and linezolid are commonly prescribed antibiotics. Kingella are sensitive to most penicillins and cephalosporins. Because MRSA osteoarticular infections tend to be severe, longer periods of antibiotic treatment with more frequent monitoring of inflammatory markers are sometimes required to obtain a complete cure with no residual complications. To assist management, we have included a clinical decision tree with antibiotic treatment protocols.

Editor’s Note: Correspondence should be addressed to Dr. Grose, The Pediatric Infectious Disease Journal, Department of Pediatrics, University of Iowa Hospital, 200 Hawkins Drive, Iowa City, IA 52242. Fax: 319-356-4855; E-mail: Every letter must contain the writer's name and address; these will be omitted in publication on request. Submitted questions will be answered and published at the discretion of the Editor. Receipt of all letters will be acknowledged.

Accepted for publication February 21, 2008.

© 2008 Lippincott Williams & Wilkins, Inc.