Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Two Consecutive Large Outbreaks of Salmonella enterica Serotype Agona Infections in Infants Linked to the Consumption of Powdered Infant Formula

Brouard, Cécile MPH*†; Espié, Emmanuelle DVM, MPH*; Weill, Francois-Xavier MD; Kérouanton, Annaëlle PhD§; Brisabois, Anne PhD§; Forgue, Anna-Maria RN; Vaillant, Véronique MD, MPH*; de Valk, Henriette MD, MPH*

The Pediatric Infectious Disease Journal: February 2007 - Volume 26 - Issue 2 - p 148-152
doi: 10.1097/01.inf.0000253219.06258.23
Original Studies

Background: An increase of isolation of Salmonella Agona was observed in January through February 2005 among infants in France.

Methods: Case–control study, food trace-back and microbiologic investigations were promptly carried out.

Results: A total of 141 confirmed cases <12 months of age were identified. Most had diarrhea (99%; bloody 56%) and fever (75%) and 36% were hospitalized for 5 days on average and none died. In the case–control analysis, all 23 cases and none of the 23 controls had consumed powdered formula of brand A (P < 10−5). Active follow up of all cases showed that after the withdrawal of formula A, cases that had consumed formula A decreased rapidly, but new cases had consumed another formula (brand B). The trace-back found that 5 batches of formula B had been manufactured on the same production line as formula A. Forty-four cases were linked to formula A and 92 to formula B. All routine controls performed by the producers were negative for Salmonella. However, enhanced microbiologic investigations yielded S. Agona in one of 176 samples of formula A, in 4 of 27 tins of formula B consumed by cases and in 6 of 420 environmental swabs from the production line. All clinical, food and environmental isolates were of the same pulsed-field gel electrophoresis profile.

Conclusions: Powdered infant formulas are not sterile products and may contain low levels of Salmonella. Routine microbiologic controls are insufficient to detect a low-grade contamination, which may cause serious illness and outbreaks among infants.

From the *Institut de veille sanitaire, Saint-Maurice, France; †Programme de formation à l’épidémiologie de terrain (PROFET), Saint-Maurice, France; ‡Centre national de référence des Salmonella, Institut Pasteur, Paris, France; §Agence française de sécurité sanitaire des aliments, Laboratoire d’études et de recherches sur la qualité des aliments et sur les procédés agro-alimentaires, Maisons-Alfort, France; ∥Direction départementale des affaires sanitaires et sociales de Seine-Maritime, Rouen, France.

Accepted for publication November 10, 2006.

Financial support provided by Institut de veille sanitaire, a state agency that receives only public funding.

Address for correspondence: Cécile Brouard, MPH, Institut de veille sanitaire, Département des maladies infectieuses, 12 rue du Val d’Osne, 94415 Saint-Maurice, Cedex, France. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.