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Diagnosis of Pediatric Human Immunodeficiency Virus Infection in Resource-Constrained Settings

Ginsburg, Amy Sarah MD, MPH; Miller, Anna MBChB; Wilfert, Catherine M. MD

The Pediatric Infectious Disease Journal: November 2006 - Volume 25 - Issue 11 - p 1057-1064
doi: 10.1097/01.inf.0000243157.16405.f0
Review Article

The majority of children infected with human immunodeficiency virus live in resource-constrained settings and die without an established diagnosis. Definitive laboratory diagnosis in children younger than 12–18 months requires virologic testing; however, antibody testing is often the only option available. Antibody testing provides a definitive diagnosis in older children but is frequently not used. Children meeting clinical criteria should be treated regardless of availability of laboratory diagnoses.

From the Elizabeth Glaser Pediatric AIDS Foundation, Santa Monica, CA.

Accepted for publication August 17, 2006.

Supported by the United States Agency for International Development, the Centers for Disease Control and Prevention, Johnson & Johnson, Boehringer Ingelheim, Jeweler's Charity Fund, the Bill and Melinda Gates Foundation, Oprah Winfrey Foundation and Ronald McDonald House Charities.

Address for correspondence: Amy Sarah Ginsburg, MD, MPH, Elizabeth Glaser Pediatric AIDS Foundation, 2950 31st Street, Suite 125, Santa Monica, CA 90405. E-mail

© 2006 Lippincott Williams & Wilkins, Inc.