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Effectiveness of Inactivated Influenza Vaccine for Prevention of Otitis Media in Children

Ozgur, Senem Konuk MD*; Beyazova, Ufuk MD*; Kemaloglu, Yusuf Kemal MD; Maral, Isil MD; Sahin, Figen MD*; Camurdan, Aysu Duyan MD*; Kizil, Yusuf MD; Dinc, Erdem MD; Tuzun, Hakan MD

The Pediatric Infectious Disease Journal: May 2006 - Volume 25 - Issue 5 - p 401-404
doi: 10.1097/01.inf.0000217370.83948.51
Original Studies

Objective: The objective of this study was to evaluate the effectiveness of inactivated influenza vaccine in preventing acute otitis media (AOM) and otitis media with effusion (OME) in children aged 6 to 60 months who attend day care.

Study Design: This prospective, single-blind study was conducted in 8 day care centers in Ankara, Turkey. One hundred nineteen (61 vaccinated and 58 unvaccinated against influenza) healthy children were examined at study entry and at 6-week intervals for 6 months by the same 2 otorhinolaryngologists who were blinded about the vaccination status of the children. The frequency of AOM and OME is compared between the 2 groups and the effect of influenza season on frequency of episodes was evaluated. Based on national influenza laboratory data, the influenza season was determined to be the period between December 15, 2003, and January 31, 2004.

Result: The frequencies of AOM, OME and total otitis media episodes in vaccinated children were 2.3%, 22.8% and 25.2%, respectively, and these frequencies were 5.2%, 31.1% and 36.3% in the unvaccinated group. The difference was statistically significant (P < 0.01). This difference was especially prominent in the influenza season (P < 0.05).

Conclusion: Influenza vaccine is effective in reducing AOM and OME episodes in 6- to 60-month-old day care children, especially during influenza season.

From the Departments of *Pediatrics, †Otorhinolaryngology and ‡Public Health, Gazi University Medical Faculty, Ankara, Turkey.

Accepted for publication January 24, 2006.

Address for correspondence: Ufuk Beyazova, MD, Gazi University Medical Faculty, Department of Pediatrics, Besevler Ankara, Turkey 06510; E-mail

© 2006 Lippincott Williams & Wilkins, Inc.