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Ten-Year Study on the Effect of Intrapartum Antibiotic Prophylaxis on Early Onset Group B Streptococcal and Escherichia coli Neonatal Sepsis in Australasia

Daley, Andrew J. MBBS, FRACP, FRCPA*; Isaacs, David MD, FRACP, FRCPCHand the Australasian Study Group for Neonatal Infections

The Pediatric Infectious Disease Journal: July 2004 - Volume 23 - Issue 7 - p 630-634
doi: 10.1097/01.inf.0000128782.20060.79
Original Studies

Background: Intrapartum antibiotics have reduced the incidence of neonatal early onset (EO) group B streptococcal (GBS) disease. Some surveillance data suggest that this success may be at the cost of increasing rates of non-GBS infection, especially in premature neonates.

Objective: To examine rates of EOGBS infection and EO Escherichia coli neonatal sepsis in Australasia.

Methodology: Analysis of trends in EO (<48 h age) GBS and E. coli sepsis from longitudinal prospective surveillance data collected from representative tertiary obstetric hospitals in each state of Australia and selected centers in New Zealand during a 10-year period from 1992 through 2001. Statistical analysis used Poisson regression.

Results: 206 GBS and 96 E. coli cases occurred in 298,319 live births during the study period. The EOGBS sepsis rate fell from a peak of 1.43/1000 live births in 1993 to 0.25/1000 in 2001 (P < 0.001). The overall EO E. coli sepsis rate was 0.32/1000. In babies with birth weight <1500 g, it was 6.20/1000. There was an overall trend to decreasing EO E. coli sepsis (P = 0.07), and there was no significant change in E. coli sepsis in babies <1500 g (P = 0.60). Sixty-nine percent of E. coli cases occurred in the <1500 g cohort; the case fatality rate in this group was 50%. The overall case fatality rate from E. coli sepsis was 36%, and this rate remained stable during the study period (P = 0.47).

Conclusions: The increasing use of intrapartum antibiotics produced a steady decline in EOGBS disease in Australasia. There was also a trend to decreasing EO E. coli sepsis in all babies, and the rate in very low birth weight infants remained stable.

Accepted for publication February 25, 2004.

Address for reprints: Dr. Andrew Daley, Department of Microbiology and Infectious Diseases, Royal Children's Hospital, Flemington Road, Parkville, Victoria, 3052, Australia. Fax 61 3 9345 5764; E-mail

© 2004 Lippincott Williams & Wilkins, Inc.