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Effect of Highly Active Antiretroviral Therapy on Cardiovascular Involvement in Children With Human Immunodeficiency Virus Infection

Plebani, Anna MD*; Esposito, Susanna MD*; Pinzani, Raffaella MD*; Fesslova, Vlasta MD; Bojanin, Jelena MD*; Salice, Patrizia MD; Rossi, Matteo MD*; Principi, Nicola MD*

The Pediatric Infectious Disease Journal: June 2004 - Volume 23 - Issue 6 - p 559-563
doi: 10.1097/01.inf.0000130073.48745.a6
Instructive Cases

The impact of highly active antiretroviral therapy (HAART) on cardiovascular involvement was evaluated in 38 vertically human immunodeficiency virus-infected children followed up for 5 years. This study demonstrates for the first time in a cohort of children the resolution of previous dilated cardiomyopathy after the start of HAART and the absence of cardiovascular events related to metabolic abnormalities during the period of its administration.

From the *Institute of Pediatrics, University of Milan, Milan, Italy, and the †Division of Pediatric Cardiology, Istituti Clinici di Perfezionamento, Milan, Italy

Address for reprints: Nicola Principi, MD, Institute of Pediatrics, University of Milan, Via Commenda 9, 20122 Milan, Italy. Fax 39-02-50320226; E-mail

© 2004 Lippincott Williams & Wilkins, Inc.