INTUSSUSCEPTION AND ROTAVIRUS VACCINES: WHAT IS THE BACKGROUND RISK?Sáez-Llorens, Xavier M.D.; Guevara, Javier Nieto M.D.The Pediatric Infectious Disease Journal: April 2004 - Volume 23 - Issue 4 - p 363-365 Brief Reports Abstract Author Information The first rotavirus vaccine was associated with a small, albeit statistically significant, risk of intussusception in immunized infants. Before results of new vaccine studies are available, we need to define the real background risk of intussusception in participating countries. A 5-year retrospective study conducted in Panama found an average rate of 1 case per 3300 infants younger than 1 year of age, with substantial yearly variations ranging from 1:2500 to 1:5000. Pediatrics University of Panama Infectious Diseases Hospital del Niño Panama City, Panama Reprints not available Accepted for publication Dec. 5, 2003. © 2004 Lippincott Williams & Wilkins, Inc.