Ina 24-month-old girl with acute lymphoblastic leukemia and invasive aspergillosis, only combination therapy with liposomal amphotericin B and caspofungin achieved a good response. Combination therapy could be a useful treatment option in children with invasive fungal disease, but before it can be routinely recommended, carefully controlled in vivo studies and well-designed randomized clinical trials are needed.
From the Departments of Pediatric Hematology and Oncology, Children′s Hospital III (ZE, JS, TK, TL) and Pediatric Radiology (HS), University of Frankfurt, Frankfurt; Children’s Hospital, Städtische Kliniken, Karlsruhe (WD); and Robert Koch-Institute (KT) and Hospital Sankt Gertrauden (GJ), Berlin, Germany.
Accepted for publication March 24, 2003.
Address for reprints: Thomas Lehrnbecher, M.D., Department of Pediatric Hematology and Oncology, Children′s Hospital III, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt. Fax 49-69-6301-6700; E-mail firstname.lastname@example.org.