ARTICLE: PDF OnlyProspective comparison of the immune response of infants to three Haemophilus influenzae type b vaccinesTURNER, RONALD B. MD; CIMINO, CAROLYN O.; SULLIVAN, BRADLEY J. MD Author Information From the Medical University of South Carolina, Charleston, SC (RBT); Praxis Biologics, Inc., Rochester, NY (COC); and the Marshfield Clinic, Marshfield, WI (BJS). The Pediatric Infectious Disease Journal: February 1991 - Volume 10 - Issue 2 - p 108-112 Free Abstract The antibody response to three Haemophilus influenzae type b vaccines was examined in 134 infants 17 to 22 months of age. Sera were collected from each subject before and 1 month after vaccination with either purified H. influenzae type b capsular polysaccharide (polyribosyl-ribitol phosphate (PRP) or one of two protein-conjugated vaccines (PRP-D or HbOC). Comparison of the two conjugate vaccines revealed that HbOC produced an antibody response ± 1.0 μg/ml in 96% compared with 72% who were vaccinated with PRP-D (P < 0.05). The isotype distribution of the antibodies produced by the two vaccines was similar. While all of the vaccines resulted in higher concentrations of anticapsular IgG1 than IgG2, the IgG1:IgG2 ratio was significantly higher in subjects immunized with HbOC. The IgG1:IgG2 ratio was similar in subjects immunized with PRP or PRP-D. The clinical significance of these observations remains to be determined. © Williams & Wilkins 1991. All Rights Reserved.
