ARTICLE: PDF OnlyInterleukin 6 activity in infants and children with bacterial meningitisRUSCONI, FRANCA MD; PARIZZI, FRANCA MD; GARLASCHI, LAURA BSC; ASSAEL, BAROUKH M. MD; SIRONI, MARINA BSC; GHEZZI, PIETRO BSC; MANTOVANI, ALBERTO MD Author Information From the Department of Pediatrics II, University of Miiano (FR, BMA), Ospedale S. Gerardo, Monza (FP), Department of Microbiology, ICP (LG), and Instituto Mario Negri (MS, PG, AM), Milan, Italy. The Pediatric Infectious Disease Journal: February 1991 - Volume 10 - Issue 2 - p 117-121 Free Abstract Concentrations of interleukin 6 (IL-6) in cere-brospinal fluid (CSF) and serum of infants and children with bacterial meningitis were determined and correlations were sought with other indices of inflammation and with outcome. Forty-two patients ages 1 month to 15 years (mean, 2.5 years) were studied. IL-6 activity was detectable (>50 units/ml) in 30 of 36 CSF samples collected at admission from patients with meningitis and in 1 of 23 controls with fever and normal CSF findings. Mean values were 36000 units/ml (range, 151–156000). IL-6 activity in CSF persisted during the first 5 days of illness. IL-6 concentrations at admission were not associated with clinical findings, CSF leukocyte, protein and glucose concentrations, serum C-reactive protein concentration and neurologic complications or sequele. © Williams & Wilkins 1991. All Rights Reserved.