ARTICLE: PDF OnlyImipenem/cilastatin treatment of bacterial meningitis in childrenWONG, VICTOR K. MD; WRIGHT, HARRY T. JR. MD; ROSS, LAWRENCE A. MD; MASON, WILBERT H. MD; INDERLIED, CLARK B. PHD; KIM, KWANG SIK MD Author Information From the Departments of Pediatrics (VKW, HTW, LAW, WHM, KSK) and Pathology (CBI), Children's Hospital of Los Angeles, USC School of Medicine, Los Angeles, CA. VKW is currently at the Department of Pediatrics, Southern California Kaiser Permanente Medical Center, Downey, CA. The Pediatric Infectious Disease Journal: February 1991 - Volume 10 - Issue 2 - p 122-125 Buy Abstract The safety and efficacy of imipenem/cilastatin were evaluated in 21 children, ages 3 to 48 months, with bacterial meningitis. Eradication of bacteria from the cerebrospinal fluid was demonstrated within 24 hours of antibiotic therapy in all but 2 patients who had Haemophilus influenzae type b meningitis and ultimately achieved bacteriologic cure after 2 to 3 days of imipenem/cilastatin therapy. Cerebrospinal fluid penetrations of imipenem and cilastatin were determined at various times after drug administration with mean cerebrospinal fluid: serum ratios of 14 and 10% for imipenem and cilastatin, respectively. The study was terminated when 7 (33%) patients developed seizure activity after antibiotic therapy was administered. The usefulness of imipenem/cilastatin for the treatment of bacterial meningitis in children may be limited by a possible increased incidence of drug-related seizure activity. © Williams & Wilkins 1991. All Rights Reserved.