Hereditary Multiple Exostosis and Pain : Journal of Pediatric Orthopaedics

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Hereditary Multiple Exostosis and Pain

Darilek, Sandra MS*; Wicklund, Catherine MS†; Novy, Diane PhD‡; Scott, Allison MD§; Gambello, Michael MD, PhD*; Johnston, Dennis PhD¶; Hecht, Jacqueline PhD*

Author Information

From *Department of Pediatrics, University of Texas-Houston Medical School, Houston, Texas; †Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas-Houston Medical School, Houston, Texas; ‡Department of Anesthesiology, University of Texas-Houston Medical School, Houston, Texas; §Shriners Hospital for Children, Houston, Texas; and ¶Department of Biomathematics, University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Study conducted at the University of Texas Health Science Center, Houston, Texas.

The MHE Coalition (http://www.mhecoalition.com) provided partial funding for this study. None of the authors received any additional financial support.

Reprints: Jacqueline T. Hecht, PhD, Department of Pediatrics, University of Texas-Houston Medical School, P.O. Box 20708, Houston, TX 77225-0708 (e-mail: [email protected]).

Journal of Pediatric Orthopaedics 25(3):p 369-376, May 2005. | DOI: 10.1097/01.bpo.0000150813.18673.ad

Abstract

This study was undertaken to characterize pain in individuals with hereditary multiple exostosis (HME). Two hundred ninety-three patients with HME completed a questionnaire designed to assess pain as well as its impact on their life. Eighty-four percent of participants reported having pain, indicating that pain is a real problem in HME. Of those with pain, 55.1% had generalized pain. Two factors were found to be associated with pain outcome: HME-related complications and surgery. Individuals who had HME-related complications were five times more likely to have pain, while those who had surgery were 3.8 more likely to have pain. No differences were found between males and females with respect to pain, surgery, or HME-related complications. The results of this study indicate that the number of individuals with HME who have pain has been underestimated and that pain is a problem that must be addressed when caring for individuals with HME.

© 2005 Lippincott Williams & Wilkins, Inc.

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