^*Department of Orthopaedics Masaryk Hospital

^‡Faculty of Health Studies, Jan Evangelista Purkyne University Usti nad Labem

^†Second Faculty of Medicine Charles University

^§Institute of Physiology of the Czech Academy of Sciences, Prague Czech Republic

All procedures have been performed in accordance with the ethical standards in the 1964 Declaration of Helsinki.

Institutional approval for the present study was obtained from the ethical committee of the Institute of Physiology of the Czech Academy of Sciences, v.v.i., and the parents of all patients provided written, informed consent to participate.

T.N. and A.E. have received funding from the Ministry of Health of the Czech Republic Department Program for Research and Development (n. 17-31564A). T.N. and A.E. have received funding from the Masaryk Hospital, Krajska zdravotni a.s., Usti nad Labem, Czech Republic (grant No. IGA-KZ-217116002)

The authors declare no conflicts of interest.