Evidence Based MedicineEvidence-based Medicine in Pediatric Orthopaedics: Evidence-based Practice Committee Summary of Levels of Evidence, Clinical Practice Guidelines, Appropriate Use Criteria, and Best Practice GuidelinesGandhi, Jigar S. PharmD*; Shea, Kevin G. MD†; Sponseller, Paul D. MD‡; Brighton, Brian K. MD§; Ganley, Theodore J. MD*; POSNA Evidence Based Practice CommitteeAuthor Information *Department of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Philadelphia, PA †Department of Orthopaedic Surgery, St. Luke’s Health System, Boise, ID ‡Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD §Department of Orthopaedic Surgery, Carolinas Healthcare System, Charlotte, NC ∥Pediatric Orthopaedic Society of North America This study received no funding from any source. Names of POSNA EBM committee members: see Appendix. The authors declare no conflicts of interest. Reprints: Theodore J. Ganley, MD, Department of Orthopaedic Surgery, Division of Orthopaedic Surgery, Children’s Hospital of Philadelphia, 34th and Civic Center Boulevard, Wood Building, 2nd Floor, Philadelphia, PA 19104. E-mail: [email protected]. Journal of Pediatric Orthopaedics: July 2018 - Volume 38 - Issue 6 - p e349-e353 doi: 10.1097/BPO.0000000000001185 Buy Metrics Abstract The concept of evidence-based medicine has evolved over the past 2 decades, and has become a cornerstone to clinical decision-making in virtually every aspect of medicine. With a commitment to providing its members with high-quality evidence-based guidelines, the American Academy of Orthopaedic Surgeons has instituted concerted efforts since 2006 to develop clinical practice guidelines (CPGs) and appropriate use criteria (AUCs) for certain orthopaedic conditions. Many of these CPGs and AUCs detail the management of pediatric orthopaedic conditions. By the same token, members of the Pediatric Orthopaedic Society of North America (POSNA) Evidence Based Practice Committee have been publishing succinct evaluations of randomized controlled trials in pediatric orthopaedic surgery to create an evidence-based repository for quick reference to available high-level evidence as well as resource to identify gaps in the current research and identify opportunities for future investigation. In instances where higher-level evidence needed to develop CPGs is not available to address a critically important clinical question, consensus recommendations from experts in the field have been obtained to develop best practice guidelines (BPGs). The purpose of this review is to provide readers with a deeper understanding of the key principles of evidence-based medicine and methodologies used for the development of CPGs, AUCs, and BPGs. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.