Demographic Differences in Adolescent-diagnosed and Adult-diagnosed Acetabular Dysplasia Compared With Infantile Developmental Dysplasia of the Hip

Abstract

Background: 

Acetabular dysplasia is a common cause of hip pain that can lead to premature osteoarthritis. This study explores whether demographic characteristics of patients diagnosed with acetabular dysplasia in adolescence and adulthood [adult-diagnosed dysplasia (AD)] differ from those who are diagnosed with developmental dysplasia of the hip (DDH) in infancy.

Methods: 

Database review identified 633 patients undergoing periacetabular osteotomy for dysplasia from August 1991 to January 2008. Excluding patients with syndromal conditions and 80 lacking contact information, 421 patients received a questionnaire regarding birth and family history; 324 (70.3%) completed the survey. Thirteen were excluded because of unrelated hip conditions, leaving 311 patients for analysis.

Results: 

Respondents were divided into 2 groups according to whether they had a history of DDH in infancy (102 patients) or were diagnosed in adolescence/adulthood (209 patients). Statistically significant differences (P<0.05) were found in sex distribution (female: DDH=98.0%, AD=88.0%), affected limb (left hip: DDH=33.3%, AD=19.1%), bilaterality (DDH=45.1%, AD=61.2%), and breech presentation (DDH=25.3%, AD=9.4%). Over 50% of all the respondents had a family history of hip disease; over 40% were first-order relatives. First-order family members of patients with AD had a higher incidence of hip replacement by the age of 65 (50.0% vs. 22.7%). Patients with DDH were more likely to have first-order family members with DDH (59.0% vs. 15.8%).

Conclusions: 

This study confirms demographic differences between patients diagnosed with hip dysplasia in infancy versus adolescence/adulthood and supports the hypothesis that these represent distinct forms of dysplasia. In both, there is a familial tendency toward hip disease with a higher incidence of arthroplasty in the AD group’s family members and higher frequency of infantile dysplasia in the DDH group’s family members.

Clinical Relevance: 

Infantile DDH is diagnosed with neonatal examination and patients are routinely followed into adolescence. Adolescent/adult AD is not detected until symptoms develop. Further study is needed to determine whether younger family members of patients with hip osteoarthritis should be screened to detect potentially at-risk hips.