Institutional members access full text with Ovid®

Share this article on:

Accuracy of Intramuscular Injection of Botulinum Toxin A in Juvenile Cerebral Palsy: A Comparison Between Manual Needle Placement and Placement Guided by Electrical Stimulation

Chin, Terence Y. P MBBS*; Nattrass, Gary R MD, FRCS(C), FRACS*; Selber, Paulo MD, SBOT (Br), FRACS*; Graham, H Kerr MD, FRCS (Ed), FRACS*†‡

Journal of Pediatric Orthopaedics: May-June 2005 - Volume 25 - Issue 3 - p 286-291
doi: 10.1097/01.bpo.0000150819.72608.86
Neuromuscular: Original Article

Most clinicians who perform botulinum toxin A injections for children with cerebral palsy do so using the “free-hand” or manual technique without using radiologic or electrophysiologic guidance to aid needle placement. The objective of this study was to investigate the accuracy of manual needle placement compared with needle placement guided by electrical stimulation. A total of 1,372 separate injections for upper and lower limb spasticity were evaluated in 226 children with cerebral palsy. The accuracy of manual needle placement compared with electrical stimulation was acceptable only for gastroc-soleus (>75%); it was unacceptable for the hip adductors (67%), medial hamstrings (46%), tibialis posterior (11%), biceps brachii (62%), and forearm and hand muscles (13% to 35%). The authors recommend using electrical stimulation or other guidance techniques to aid accurate needle placement in all muscles except the gastroc-soleus. Further study is needed to determine whether more accurate injecting will lead to better functional outcomes and more efficient use of botulinum toxin A.

From *Department of Orthopaedics, Royal Children's Hospital, Melbourne, Australia; †University of Melbourne, Melbourne, Australia; and ‡Hugh Williamson Gait Analysis Laboratory, Royal Children's Hospital, Melbourne, Australia.

Study conducted at the Royal Children's Hospital, Melbourne, Australia.

Presented at the 2003 Annual Meeting of the American Academy of Developmental Medicine and Cerebral Palsy, Montreal, Canada, October 2003.

None of the authors received financial support for this study.

Reprints: H. Kerr Graham, MD, FRCS (Ed), FRACS, Department of Orthopaedics, Royal Children's Hospital, Flemington Road, Parkville 3052, Victoria, Australia (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.