Eosinophilic granuloma of bone is a rare skeletal manifestation of one of the spectrum of diseases known as histiocytosis X. These lesions often simulate other pathophysiologic processes (Ewing sarcoma, chronic osteomyelitis, Brodie abscess, and chondroblastoma) and may present significant diagnostic problems. Three additional cases of eosinophilic granuloma in an epiphysis are reviewed in this report. Transphyseal extension was present in all our cases and in five of 10 cases documented in the literature. Diagnosis demands accurate biopsy and histopathologic evaluation. Treatment and prognosis are individualized.
Departments of *Orthopaedics and †Pathology and *Musculoskeletal Tumor Center, University Hospitals, Cleveland, Ohio, U.S.A.
Address correspondence and reprint requests to Dr. Leeson at his present address: 400 Wabash Avenue, Akron General Medical Center, Ambulatory Care Building. Akron. OH 44307, U.S.A.
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