Original ArticlesImplications of Diphenhydramine Single-Dose Unintended Ingestions in Young ChildrenStojanovski, Sasko D. PharmD*†; Baker, S. David PharmD‡§; Casavant, Marcel J. MD*‡§∥; Hayes, John R. PhD†§; Robinson, Renee F. PharmD, MPH*†‡§∥; Nahata, Milap C. PharmD, MS*†§∥Author Information *College of Pharmacy, Ohio State University; †Children's Research Institute; ‡Central Ohio Poison Center; §Children's Hospital and ∥Colleges of Medicine, Ohio State University, Columbus, OH. Address correspondence and reprint requests to Milap C. Nahata, PharmD, MS, College of Pharmacy, Ohio State University, 500 W 12th Ave, Columbus, OH 43210. E-mail: [email protected]. Pediatric Emergency Care: July 2007 - Volume 23 - Issue 7 - p 465-468 doi: 10.1097/01.pec.0000280510.75418.31 Buy Metrics Abstract Background: Diphenhydramine is frequently used in children, but the consequences of single unintended dose exposures in young children are unknown. Methods: We evaluated 2000-2001 American Association of Poison Control Centers-Toxic Exposure Surveillance data on children exposed to diphenhydramine ingestions. Results: Nine hundred twenty-six cases met the inclusion criteria; 49.1% were men, mean age was 29.7 ± 13.0 months (range, 1-72 months). Approximately 85% of unintentional exposures occurred in 1- to 3-year-old children. The mean dose ingested was 6.4 ± 6.1 mg/kg (median, 4.6 mg/kg). Thirty-two percent of patients were symptomatic: minor (29.4%), moderate (2.9%), and severe (0.11%). There was no relationship between dose and symptom severity. Diphenhydramine dose ingestion of 7.5 mg/kg or greater was not a predictor of severity (P = 0.47) Conclusions: The relationship between ingested dose and severity of symptoms was insignificant. © 2007 Lippincott Williams & Wilkins, Inc.