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Safety and efficacy of rocuronium for controlled intubation with paralytics in the pediatric emergency department

MENDEZ, DONNA R. MD; GOTO, COLLIN S. MD; ABRAMO, THOMAS J. MD; WIEBE, ROBERT A. MD

ORIGINAL ARTICLES
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Background Controlled intubation in the pediatric emergency department (ED) requires a paralytic agent that is safe, efficacious, and of rapid onset. The safety of succinylcholine has been challenged, leading some clinicians to use vecuronium as an alternative. Rocuronium’s onset is similar to that of succinylcholine.

Objective To evaluate the safety and efficacy of rocuronium for controlled intubation with paralysis (CIP) in the pediatric ED.

Methods A retrospective, observational study reviewed the records of patients less than 15 years of age, who received controlled intubation with paralytics at two Dallas EDs. The patients received either vecuronium or rocuronium.

Results The study included 84 patients (vecuronium 19, rocuronium 65). Complications were similar between the two groups. Rocuronium had a shorter time from administration to intubation when compared to vecuronium (P < 0.05).

Conclusion Rocuronium is as safe and efficacious as vecuronium for CIP in the pediatric ED.

From the Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas and The Division of Pediatric Emergency Medicine, Children’s Medical Center, Dallas, Texas.

Address for reprints: Donna Reyes Mendez, MD, 3623 Kennedy Drive, Pearland, TX 77584; e-mail: drmendez@texaschildrenshospital.org

© 2001 Lippincott Williams & Wilkins, Inc.