CME Review ArticleBehavioral Management of Children With Autism in the Emergency DepartmentWolpert, Katherine H. MD∗; Kodish, Ian MD, PhD†; Kim, Soo-Jeong MD†‡; Uspal, Neil G. MD∗ Author Information From the ∗Assistant Professor (Wolpert) and Associate Professor (Uspal), Division of Emergency Medicine, Department of Pediatrics, University of Washington †Associate Professor (Kim and Kodish), Department of Psychiatry and Behavioral Sciences, University of Washington ‡Seattle Children's Autism Center, Seattle, WA. Dr. Uspal discloses that the U.S. Food and Drug Administration has not approved the use of olanzapine for the treatment of agitation in children, as discussed in this article. Please consult the product’s labeling for approved information. Reprints: Katherine Wolpert, MD, 4800 Sand Point Way NE, Mail-Stop MB.7.520 Seattle WA, 98105 (e-mail: [email protected]). Pediatric Emergency Care 39(1):p 45-50, January 2023. | DOI: 10.1097/PEC.0000000000002886 Buy CME Test Metrics Abstract Autism spectrum disorder (ASD) is characterized by impaired social communication in conjunction with patterned behaviors. Often associated with emotional dysregulation, irritability, aggression, depression, and suicidality, ASD youth frequently present to the emergency department for behavioral and mental health evaluation. Psychiatric comorbidities, agitation, and depression are commonly encountered. During these visits, practitioners must thoughtfully consider organic etiologies for presenting symptoms, formulate plans to address risk of agitation, and understand how to effectively formulate disposition options in this patient population. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.