CME Review ArticleDiagnosis and Management of Pediatric Venous Thromboembolism New Therapies on the HorizonDoshi, Bhavya S. MD∗,†; Ellison, Angela M. MD, MSc∗,‡Author Information From the ∗Instructor and Associate Professor, Department of Pediatrics, Perelman School of Medicine at The University of Pennsylvania †Division of Hematology ‡Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. The authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interest in, any commercial organizations relevant to this educational activity. Reprints: Bhavya Doshi, MD, 3501 Civic Center Blvd, CTRB 5024, Philadelphia, PA 19104 (e-mail: [email protected]). Pediatric Emergency Care: May 2021 - Volume 37 - Issue 5 - p 273-279 doi: 10.1097/PEC.0000000000002431 Buy Take the CME Test Metrics Abstract The incidence of venous thromboembolism (VTE) is increasing in pediatric patients. Prompt recognition and evaluation of VTE in young patients could prevent significant morbidity or mortality. In contrast to VTE in adults, current treatment guidelines are largely based on expert opinion as limited randomized controlled trial data exist about the appropriate management in pediatric patients with traditional anticoagulants. However, recently approved direct-acting oral anticoagulants in adults are also being investigated in pediatric VTE and these data could inform future evidence-based treatment principles. Thus, healthcare providers must be well informed about the management of pediatric VTE and the data from these trials to date. This continuing medical education article will provide a summary of management of pediatric VTE with particular emphasis on emerging direct-acting oral anticoagulants. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.