CME Review ArticleSecond-Generation Antipsychotic Use in Pediatric Emergency MedicineLambert, Clare∗; Panagiotopoulos, Constadina MD, FRCPC†; Davidson, Jana MD, FRCPC‡; Goldman, Ran D. MD, FRCPC§Author Information From the ∗Trainee, The Pediatric Research in Emergency Therapeutics (PRETx) Program, Division of Pediatric Emergency Medicine †Clinical Professor, Division of Endocrinology, Department of Pediatrics ‡Clinical Professor, Department of Psychiatry §Professor, The Pediatric Research in Emergency Therapeutics (PRETx) Program, Division of Pediatric Emergency Medicine, University of British Columbia; BC Children’s Hospital Research Institute, Vancouver, BC, Canada. The authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interest in, any commercial organizations relevant to this educational activity. Reprints: Ran D. Goldman, MD, Division of Pediatric Emergency Medicine, BC Children's Hospital (e-mail: [email protected]). Pediatric Emergency Care: March 2021 - Volume 37 - Issue 3 - p 161-164 doi: 10.1097/PEC.0000000000002387 Buy CME Test Metrics Abstract In recent years, the number of patients presenting to the emergency department with mental health complaints has been growing, alongside an increase in second-generation antipsychotic (SGAs) prescriptions for a variety of mental health conditions. Children treated with SGAs may have abnormalities, such as rapid weight gain and central adiposity, glucose intolerance, dyslipidemia, and hypertension; they may present to the pediatric emergency department with components of metabolic syndrome or type 2 diabetes, and a subsequent significant risk for cardiovascular complications later in life. Pediatric emergency department providers may serve as a safety net for patients to detect SGA-related metabolic complications, especially among vulnerable populations lacking access to primary care or psychiatric services. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.