Special FeaturesPediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2 A Case Series Quantitative Systematic ReviewBustos B, Raúl MD∗; Jaramillo-Bustamante, Juan Camilo MD†,‡; Vasquez-Hoyos, Pablo MD, MSc§,∥,¶; Cruces, Pablo MD#,∗∗; Díaz, Franco MD, MBA∗∗,††,‡‡,§§Author Information From the ∗Unidad de Cuidados Intensivos Pediátricos, Clínica Sanatorio Alemán y Hospital Guillermo Grant Benavente, Concepción, Chile †Unidad de Cuidados Intensivos Pediátricos, Hospital General de Medellín ‡Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Medellín §Departamento de Pediatría, Universidad Nacional de Colombia ∥Departamento de Pediatría, Fundacion Universitaria de Ciencias de la Salud ¶Sociedad de Cirugía, Hospital de San José, Bogotá, Colombia #Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello ∗∗Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú ††Unidad de Paciente Crítico Pediátrico, Hospital Clínico La Florida Dra. Eloísa Díaz Insunza ‡‡Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú §§Instituto de Ciencias e Innovación en Medicina (ICIM), Universidad del Desarrollo, Santiago, Chile. Disclosure: The authors declare no conflict of interest. Reprints: Franco Díaz, MD, MBA, Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú, Camino A Rinconada 1201, Maipú, Santiago, Chile (e-mail: [email protected]). Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.pec-online.com). Pediatric Emergency Care: January 2021 - Volume 37 - Issue 1 - p 44-47 doi: 10.1097/PEC.0000000000002306 Buy SDC Metrics Abstract Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July 1, 2020. We found a myriad of clinical features, but we were able to describe common characteristics: previously healthy school-aged children, persistent fever and gastrointestinal symptoms, lymphopenia, and high inflammatory markers. Clinical syndromes such as myocarditis and Kawasaki disease were present in only one third of cases each one. Pediatric intensive care unit admission was frequent, although length of stay was less than 1 week, and mortality was low. Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low. The PIMS-ST was recently described, and the detailed quantitative pooled data will increase clinicians’ awareness, improve diagnosis, and promptly start treatment. This analysis also highlights the necessity of future collaborative studies, given the heterogeneous nature of the PIMS-TS. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.