Special FeaturesA Novel Pediatric Multisystem Inflammatory Syndrome During the COVID-19 PandemicDel Greco, Giuseppina MD; Brady, KeriAnne MD; Clark, Barbara RN, BSN, MSN, CPNP; Park, Hannah MD, MPHAuthor Information From the Department of Emergency Medicine, NewYork-Presbyterian Queens, Queens, New York. Disclosure: The authors declare no conflict of interest. Reprints: Giuseppina Del Greco, MD, Department of Emergency Medicine NewYork–Presbyterian Queens, 5645 Main St, NY, 11355 (e-mail: GiuseppinaDazzo@gmail.com). G.D.G. conceptualized and designed the study, drafted a case report, the initial manuscript, and reviewed and revised the manuscript. K.B., H.P., and B.C. drafted case reports and reviewed and revised the manuscript. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Pediatric Emergency Care: October 2020 - Volume 36 - Issue 10 - p 500-504 doi: 10.1097/PEC.0000000000002229 Buy Metrics Abstract In late March and early April, New York City was an epicenter of the COVID-19 pandemic. Citizens were ordered to stay at home to flatten the curve. The adult population was affected with a severe respiratory illness as well as acute kidney injury, cardiomyopathy, arrhythmia, and thromboembolism. Although children were not affected in the same manner, weeks after the peak, reports from other countries emerged about cases of pediatric patients presenting with a novel inflammatory syndrome. We present 4 patients along with their emergency department course, so providers will have a better understanding of the identification and workup of these patients. Currently, it is unclear when this inflammatory syndrome develops in respect to a COVID-19 infection. The clinical features of this syndrome seem to overlap between Kawasaki disease, toxic shock syndrome, and myocarditis. All patients presenting to our emergency department had fever, variable rash, abdominal pain, vomiting, and/or diarrhea. Patients remained persistently tachycardic and febrile despite being given proper doses of antipyretics. Severity of presentations varied among the 4 cases. All 4 patients were found to have antibodies to COVID-19. All patients required admission, but 2 required the pediatric intensive care unit for cardiac and/or respiratory support or closer monitoring. Upon follow-up on our patients, it seems that most patients are recovering with treatment, and overall, there is a low reported mortality rate. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.