Transient erythroblastopenia of childhood is a form of pure red cell aplasia that is self-limited and occurs in children 4 years old and younger. It is characterized by an absence or a significantly reduced quantity of erythroblasts in the bone marrow without underlying congenital red blood cell abnormalities. Transient erythroblastopenia of childhood should be considered in previously healthy children who present with normocytic anemia and lack of reticulocytosis without evidence of blood loss, hemolysis, or other causes of bone marrow suppression. Evaluation should be targeted at ruling out other causes of anemia. Management is mainly supportive, although some children may require blood transfusions for symptomatic anemia. Most patients demonstrate a return of hematopoiesis within two weeks of diagnosis and normalization of blood counts within two months.
Assisstant Professor (Burns), Department of Pediatrics, Division of Pediatric Emergency Medicine, University of Washington and Seattle Children's Hospital, Seattle, WA; Professor of Pediatrics (Woodward), Division Chief of Emergency Medicine, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, WA.
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Reprints: Rebekah A. Burns, MD, Division of Pediatric Emergency Medicine, University of Washington and Seattle Children's Hospital, 4800 Sand Point Way NE, Mail Stop M.B.7.520, Seattle, WA 98105 (e-mail: Rebekah.firstname.lastname@example.org).