CME Review ArticleLiquid Nicotine ToxicityKim, Ji Won MD; Baum, Carl R. MD, FAAP, FACMTAuthor Information Pediatric Emergency Medicine Fellow (Kim) and Professor of Pediatrics (Baum), Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT. The authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interest in, any commercial organizations pertaining to this educational activity. Reprints: Ji Won Kim, MD, Section of Pediatric Emergency Medicine, Department of Pediatrics, Yale University School of Medicine, 100 York St, Suite 1F, New Haven, CT 06511 (e-mail: firstname.lastname@example.org). Pediatric Emergency Care: July 2015 - Volume 31 - Issue 7 - p 517–521 doi: 10.1097/PEC.0000000000000486 Buy Take the CME Test Metrics Abstract E-cigarettes, also known as electronic nicotine delivery systems and electronic cigarettes, are advertised as a healthier alternative product to tobacco cigarettes despite limited data on the consequences of e-cigarette use. Currently, there are no US Food and Drug Administration or other federal regulations of e-cigarettes, and calls to poison control centers regarding liquid nicotine toxicity, especially in children, are on the rise. This article presents the background and mechanism of action of e-cigarettes as well as up-to-date details of the toxicity of liquid nicotine. We also present management strategies in the setting of liquid nicotine toxicity. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.