CME Review ArticleReview of the Use of Lipid Emulsion in Nonlocal Anesthetic PoisoningKostic, Mark A. MD*†; Gorelick, Marc MD†Author Information *Associate Medical Director, Wisconsin Poison Center and †Associate Professor of Pediatrics and Emergency Medicine (Kostic); Professor of Pediatric Emergency Medicine (Gorelick), Medical College of Wisconsin, Milwaukee, WI. The authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interest in, any commercial organizations pertaining to this educational activity. Reprints: Mark A. Kostic, MD, Medical College of Wisconsin, 999 N 92nd St, Suite 660, Milwaukee, WI 53266 (e-mail: firstname.lastname@example.org). Pediatric Emergency Care: June 2014 - Volume 30 - Issue 6 - p 427-433 doi: 10.1097/PEC.0000000000000155 Buy SDC Take the CME Test Metrics Abstract Intravenous lipid emulsion (ILE) has been used widely for the treatment of poisoning due to local anesthetic agent and is increasingly reported as a therapy for other forms of poisoning. This article will review the proposed mechanisms of action for ILE in poisoning and the evidence from animal studies and human experience supporting the use of ILE for poisoning due to nonlocal anesthetic agents. © 2014 Lippincott Williams & Wilkins, Inc.