ORIGINAL ARTICLESCoagulation testing in pediatric blunt trauma patientsHOLMES, JAMES F. MD; GOODWIN, HILLARY C. MD; LAND, CATHERINE MD; KUPPERMANN, NATHAN MD, MPHAuthor Information From the Division of Emergency Medicine, Department of Internal Medicine (J.F. Holmes, H.C. Goodwin, N. Kuppermann), and the Department of Pediatrics (C. Land, N. Kuppermann), University of California, Davis, School of Medicine, Sacramento, California. Address for reprints: James F. Holmes, MD, UC Davis Medical Center, Division of Emergency Medicine, 2315 Stockton Boulevard, PSSB, Sacramento, CA 95817–2282; e-mail: firstname.lastname@example.org We would like to thank Nicole Glaser, MD and David H. Wisner, MD for critical reviews of this manuscript. Prior Presentation: ACEP Research Forum, San Diego, California, October 11–12, 1998. Pediatric Emergency Care: October 2001 - Volume 17 - Issue 5 - p 324-328 Buy SDC Abstract Objectives To determine the prevalence of abnormal coagulation studies and to identify variables associated with markedly elevated coagulation studies in children with blunt trauma. Methods We reviewed the medical records of all patients < 15 years old hospitalized at a Level 1 trauma center for either blunt head or torso trauma over a 4-year period. Data from each patient’s emergency department (ED) presentation were abstracted. ED coagulation studies were defined prior to data analysis as elevated if the international normalized ratio (INR) was ≥1.2 or partial thromboplastin time (PTT) was ≥33.0 seconds and markedly elevated if the INR was ≥1.5 or PTT was ≥40 seconds. Variables associated with markedly elevated coagulation studies in a univariate analysis (P < 0.05) were entered into a backward elimination logistic regression analysis to identify variables independently associated with markedly elevated coagulation studies. Results A total of 1082 patients’ records were reviewed, and the 830 (77%) patients with coagulation studies obtained composed the study population. Elevated coagulation studies were detected in 232 (28%) patients, and 49 (6%) of these were found to be markedly elevated. In the multivariate analysis, a GCS ≤13 (odds ratio [OR] 8.7, 95% confidence interval [CI] 4.3, 17.7), low systolic blood pressure (OR 4.0, 95% CI 1.6, 9.9), open/multiple bony fractures (OR 2.9, 95% CI 1.4, 6.2), and major tissue wounds (OR 2.8, 95% CI 1.4, 5.6) were independently associated with markedly elevated coagulation studies. Conclusion Hospitalized pediatric blunt trauma patients frequently have minor elevations in ED coagulation studies. Marked elevations occur infrequently and are independently associated with a GCS ≤13, low systolic blood pressure, open/multiple bony fractures, and major tissue wounds. © 2001 Lippincott Williams & Wilkins, Inc.