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SHANE STEVEN A. MD; WOLLMAN, MICHAEL MD; CLAASSEN, DIANA MD
Pediatric Emergency Care: June 1994
Illustrative Cases: PDF Only
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A previously healthy adolescent female suddenly developed a severe febrile pharyngitis and impending upper airway obstruction. Her Monospot® test was positive, and her throat culture grew group A β-hemolytic streptococcus. After treatment with antibiotics and glucocorticoids, she developed a fulminant course dominated by disseminated intravascular coagulation and hepatic necrosis. At autopsy, herpes simplex virus type-1 was cultured from lung, liver, and spleen tissue. We believe this is the first report of disseminated herpes simplex infection after steroid use for upper airway obstruction.

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