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Abstract O-58: KINETIC OF MONOCYTIC HLA-DR EXPRESSION AFTER SEVERE PAEDIATRIC TRAUMA

Cour-Andlauer, F.1; Morrow, B.M.2,3; McCulloch, M.2,3; Javouhey, E.1; Lecour, S.4; van As, S.3,5; Remy, S.1,6; Monneret, G.6,7; Argent, A.C.2,3

Pediatric Critical Care Medicine: June 2018 - Volume 19 - Issue 6S - p 25
doi: 10.1097/01.pcc.0000537400.39860.dd
Oral Abstracts
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1Hospices Civils de Lyon- Hopital Femme Mère Enfant, Paediatric Intensive Care Unit, Bron, France

2Red Cross War Memorial Children’s Hospital, Paediatric Intensive Care Unit, Cape Town, South Africa

3University of Cape Town, Department of Paediatrics and Child Health, Cape Town, South Africa

4Faculty of Health Sciences- University of Cape Town, Hatter Institute for Cardiovascular Research in Africa, Cape Town, South Africa

5Red Cross War Memorial Children’s Hospital, Trauma Unit- Department of Pediatric Surgery, Cape Town, South Africa

6Hospices Civils de Lyon- Edouard Herriot Hospital, Immunology Laboratory, Lyon, France

7University Claude Bernard Lyon 1, EA 7426- Pathophysiology of injury-induced immunosuppression, Lyon, France

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Aims & Objectives:

In adults, major trauma induces immune dysfunction, with diminished expression of human leukocyte antigen DR expression on circulating monocytes (mHLA-DR). No paediatric data are available. This study described the kinetic of mHLA-DR expression following major paediatric trauma and the relationship between mHLA-DR and outcomes.

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Methods

This was a prospective observational study of children with severe brain trauma (GCS<8 or Injury Severity Score ≥16) admitted to the Paediatric Intensive Care (PICU) or Trauma (TU) units in Red Cross War Memorial Children’s Hospital, Cape Town, South Africa, between November 2016 and March 2017. Blood samples for standardized mHLA-DR measurement were collected at Day 1, Day 3 and Day 8 after injury.

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Results

Thirty-six children were included with 83 mHLA-DR measurements (Table 1). One patient withdrew after initial enrollment. mHLA-DR was lower in patients admitted to PICU compared to TU (p< 0.001). Overall, mHLA-DR nadir was at Day-1 and increased at Day-3 (p<0.001). mHLA-DR expression at Day-3 was significantly lower if inotropes were used (p=0.02) and if patients received red cell transfusion (p=0.006). mHLA-DR at Day 3 was higher in patients discharged at home at Day 30, compared to children still hospitalized or in rehabilitation at Day 30 (Table 1). In this cohort, mHLA-DR measurement was not correlated with the occurrence of secondary infection.

Table

Table

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Conclusions

As in adults, mHLA-DR decreased rapidly after severe trauma in children and may be a marker of injury severity. Further research is recommended to determine the utility of mHLA-DR at Day 3 for predicting outcome.

©2018The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies