Aims & Objectives:
Phase angle (PA), evaluated by bioelectrical impedance analysis, can be used as an indicator of cell membrane integrity and as a prognostic parameter in clinical situations. PA is determined directly from resistance and reactance and reflects body cell mass, thus may be a useful parameter for nutritional risk screening. The aim of this study was to evaluate the factors associated with PA in critically ill children.
Prospective study conducted in a Pediatric Intensive Care Unit (PICU) with children aged between 1 month and 15 years. Demographic and clinical data were assessed at admission. Bioelectrical impedance analysis, laboratorial and anthropometric measures were performed within 72 hours of admission. PICU and hospital length of stay (LOS), nosocomial infection and overall mortality were assessed. Man-Whitney, Fisher’s Test, Spearman correlation, linear and logistic regression were applied. P-value <0.05 was considered significant.
A total of 76 patients were included, 54% male, median age of 1.9 (Interquartile range (IQR) 0.33; 9.07) years and median Pediatric Index of Mortality (PIM-2) of 2.35% (IQR 0.95; 6.8) (Table 1). Lower PA was associated with higher C-reactive protein (CRP) (mg/L) (p=0.048) and with higher CRP/albumin ratio (p=0.038), even after adjustment for sex, age and PIM-2 (p=0.02 and p=0.014, respectively (Table 2). No association between PA and anthropometry (Table 2) or clinical outcomes (data not shown) were observed.
PA was associated with inflammatory markers in critically ill children. More studies are necessary to evaluate the usefulness of PA in this population.©2018The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies