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Abstract O-30: A RANDOMIZED CONTROLLED TRIAL INVESTIGATING THE EFFECT OF HIGH-ENERGY FORMULA ON WEIGHT GAIN AND GASTROINTESTINAL TOLERANCE IN POSTOPERATIVE INFANTS WITH CONGENITAL HEART DISEASE

Zhang, H.1; Gu, Y.2; Mi, Y.3; Jin, Y.3; Fu, W.3; Latour, J.4

Pediatric Critical Care Medicine: June 2018 - Volume 19 - Issue 6S - p 13–14
doi: 10.1097/01.pcc.0000537372.02635.5e
Oral Abstracts
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1Children’s Hospital of Fudan University, PICU, Shanghai, China

2Children’s Hospital of Fudan University, Nursing Department, Shanghai, China

3Children’s Hospital of Fudan University, Cardiac Intensive Unit, Shanghai, China

4Plymouth University, School of Nursing and Midwifery, Plymouth, United Kingdom

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Aims & Objectives:

To investigate the effect of high-energy formula (HF) on weight gain and gastrointestinal tolerance in postoperative infants with congenital heart disease.

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Methods

A double-blinded randomized controlled trial at a cardiac intensive care unit in a Chinese children’s hospital. Participants were infants <1 year of age after cardiac surgery and were randomly assigned to intervention group (n=32) or control group (n=32). The intervention group received HF (100 kcal/100 mL) and the control group standard formula (67 kcal/100 mL) for 7 postoperative days. Primary outcomes were weight gain and gastrointestinal intolerance; secondary outcomes were prealbumin, energy intake and standard intensive care characteristics. Final analysis included 30 infants in intervention and 29 infants in control group. Trial registration at ClinicalTrials.gov is #NCT02389491.

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Results

Infants who received HF (n=30) showed greater weight gain than those in the control group (n=29) (-0.09 ± 0.18kg/7days versus -0.30 ± 0.22kg/7days, p<0.0001). Gastrointestinal intolerance was observed in the intervention group with abdominal tympany (n=1), gastric retention (n=2), and diarrhea (n=1), while the control group had no problems. The prealnumin showed significant differences at day 7 (p=0.037). Enteral energy intake in the intervention group showed higher than control group from day 3(Figure 1).

We observed no significant differences in secondary outcomes of ICU characteristics (Table 1).

Table

Table

Figure

Figure

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Conclusions

Postoperative infants with congenital heart disease receiving HF gained more weight and experienced some gastrointestinal problems than those infants receiving standard formula. We suggest infants receiving HF were safe and effective, also need more studies to confirm it.

©2018The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies