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Pulmonary Hypertension

Oishi, Peter MD; Fineman, Jeffrey R. MD

Pediatric Critical Care Medicine: August 2016 - Volume 17 - Issue 8 - p S140-S145
doi: 10.1097/PCC.0000000000000754
Organ Systems: Cardiopathophysiology and Disorders

Objectives: To review the clinical classification, diagnosis, and pathophysiology of pulmonary hypertension in children, emphasizing the role of right ventricular function, ventricular interaction, and congenital heart disease in the evolution and progression of disease, as well as management strategies and therapeutic options.

Data Source: MEDLINE, PubMed.

Conclusions: Critically ill children with pulmonary hypertension associated with congenital heart disease are a high-risk population. Congenital cardiac defects resulting in either increased pulmonary blood flow or impaired pulmonary venous drainage predispose patients to developing structural and functional aberrations of the pulmonary vasculature. Mortality from pulmonary hypertension is most directly related to right ventricular failure.

Both authors: Division of Critical Care Medicine, Department of Pediatrics, University of California San Francisco School of Medicine, University of California San Francisco Benioff Children’s Hospital, San Francisco, CA.

Drs. Oishi and Fineman received support for article research from the National Institutes of Health.

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Copyright © 2016 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies