Poster Discussion Abstracts
Aims & Objectives:
Rationale Pediatric sepsis is the leading cause of PICU admissions and mortality. Current evidences in resuscitation of adult sepsis pointed to the importance of types of crystalloid and fluid-related complication on resuscitation outcomes, but evidences are lacking in pediatric populations.
Objectives To compare the outcomes of pediatric sepsis resuscitation with different types of crystalloid fluid.
We randomly assigned the participants into 3 groups to received NSS, RLS or Sterofundin as bolus fluid therapy. Other standard of cares were continued with primary care physicians’ judgment. Data were analysed using SPSS version 22.
31 patients were included into the study. Median age 33 mo. (IQR 21 – 60), PELODS-II score at 5 pts. (IQR 1 – 7), PRISM-III score at 5 pts. (IQR 2 – 9 pts.). Median dose of resuscitation fluid was 30 mL/kg (IQR 20 – 40). Baseline demographic data were not significantly different between 3 groups. After resuscitation, acid-base status parameters and fluid-related complications were not significantly different among groups. Subgroup analysis of patients received bolus fluid ≥ 30 mL/kg showed significant better lactate clearance after 24 hrs. in RLS group (p-value 0.046). Mortality, ventilator days, PICU & hospital LOS were not different between groups.
Resuscitation of pediatric sepsis with RLS when dosing ≥ 30 mL/kg, comparing with NSS, resulted in significant better lactate clearance at 24 hrs. after resuscitation. Balanced salt solution were not associated with significantly different rate of fluid-related complications.