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Abstract O-13: BIOMARKERS MAY PREDICT CLINICAL COURSES IN PEDIATRIC PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME

Nakagawa, S.1; Tho, B.2; Phuc, P.H.2; Ainai, A.3; Takayama, I.4; Suzuki, T.3; Thuy, P.5; Huong, D.T.5; Tuan, T.A.2; Hai, L.T.6; Nakajima, N.3

Pediatric Critical Care Medicine: June 2018 - Volume 19 - Issue 6S - p 8
doi: 10.1097/01.pcc.0000537355.69183.22
Oral Abstracts
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1National Center for Child Health and Devlopment, Critical Care Medicine, Tokyo, Japan

2Vietnam National Children’s Hospital, Pediatric Intensive Care Unit, Hanoi, Vietnam

3National Institute of Infectious Diseases, Pathology, Tokyo, Japan

4National Institute of Infectious Diseases, Influenza Virus Research Center, Tokyo, Japan

5Vietnam National Children’s Hospital, Research of Molecular Biology for Infectious Disease, Hanoi, Vietnam

6Vietnam National Children’s Hospital, Emergency Medicine, Hanoi, Vietnam

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Aims & Objectives:

Acute respiratory distress syndrome (ARDS) has high mortality. Early identification of sick patients with ARDS may help management and predict prognosis. We examined the potential roles of several biomarkers in the blood to predict the clinical outcomes in pediatric ARDS.

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Methods

Design: A prospective observational study

Setting: A Tertiary Pediatric Intensive Care Unit in Vietnam

Patients: Children from one month to 15 years old with ARDS

Interventions: Mechanical ventilation parameters were recorded in the first 12 hours and blood samples for biomarkers were collected within an hour of mechanical ventilation.

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Results

25 patients were enrolled. Age varied from 1 month to 9 years old (median 6 months). 14 males and 11 females. 24 of them had pulmonary and 1 had extra-pulmonary origin. 17 survived (68%). PaO2/FIO2 ratio (P/F) and oxygenation index (OI) were significantly different between survivors and non-survivors at 1 and 12 hours, respectively (Table). Biomarker levels including interleukin 8 (IL-8), interferon-gamma induced protein 10 (IP-10), angiopoietin 2 (Ang-2) and receptors for advanced glycation end-products (RAGE) were significantly higher in non-survivors than survivors (Table).

Table

Table

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Conclusions

Early mechanical ventilation parameters and biomarkers indicating inflammation and endothelial/epithelial injury may predict the clinical courses in pediatric ARDS patients.

©2018The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies