Abstract P-241: CONCURRENT HEMOPERFUSION AND HEMODIALYSIS FOR CHILDREN WITH ACUTE PARAQUAT INTOXICATION
Aims & Objectives:
To evaluate the efficacy of concurrent hemoperfusion and hemodialysis in children with paraquat poisoning.
46 children with paraquat-poisoning were enrolled in the study, blood purification group (between 1st June 2013 to 31st May 2017) included 34 children, 18 males and 16 females, average age:f 9.18 ± 3.94 years old. non-blood purification group (between 1st Jan 2009 to 31st May 2013)included 12 cases, 4 males and 8 females, average age 8.92 ± 3.54 years old. they were categorized into + ~+ + + + subgroups according to their urine paraquat test. Liver and kidney function and the mortality were compared and 6 months follow-up were done to evaluating the efficacy of blood purification in children with paraquat poisoning.
The blood urea nitrogen of patients from +~++++ subgroups blood purification group were 16.98 ± 7.74mmol/L 17.50 ± 6.15mmol / L, 27.88 ± 17.11 mmol / L 31.08 ± 12.45 mmol/L respectively.The mortality was 83.3%(10/12) in non-blood purification group, while the blood purification group had a 29.4%(10/34) mortality.there was a significant difference between the two groups (2 = 10.49, P = 0.001).In blood purification group, the mortality were 28.57%(2/7) in the subgroup of ++ 50% 3/6 in the subgroup of +++ 83.3%(5/6) in the subgroup of ++++ respectively.All dead patients in the blood purification group had respiratory failure.
The larger dose paraquat intake induced the severer renal function and the higher mortality;Severe lung injury is highly correlated with death in children with paraquat poisoning;Early concurrent hemoperfusion and hemodialysis would be an effective and safe treatment for children with acute paraquat intoxication.Copyright © 2017 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies